Wenjie Yu

Wenjie Yu, PhD

Research Assistant Professor
Division of Pulmonary, Critical Care, and Occupational Medicine

wenjie-yu@uiowa.edu

Select Publications

Romano Ibarra GS, Lei L, Yu W, Thurman AL, Gansemer ND, Meyerholz DK, Pezzulo AA, McCray PB, Thornell IM, Stoltz DA. IL‑13 induces loss of CFTR in ionocytes and reduces airway epithelial fluid absorption. J Clin Invest. 134(21): e181995. (2024).. https://doi.org/10.1172/JCI181995

Shao F, Phan A‑V, Yu W, Guo Y, Thompson J, Coppinger C, Venugopalan SR, Amendt BA, Van Otterloo E, Cao H. Transcriptional programs of Pitx2 and Tfap2a/Tfap2b controlling lineage specification of mandibular epithelium during tooth initiation. PLoS Genetics. 20(7): e1011364. (2024). https://doi.org/10.1371/journal.pgen.1011364

Bae H, Kim BR, Jung S, Le J, van der Heide D, Yu W, Park SH, Hilkin BM, Gansemer ND, Powers LS, Kang T, Meyerholz DK, Schuster VL, Jang C, Welsh MJ. Arteriovenous metabolomics in pigs reveals CFTR regulation of metabolism in multiple organs. J Clin Invest. 134(13)e174500. (2024). https://doi.org/10.1172/JCI174500

Jain A, Kim BR, Yu W, Moninger TO, Karp PH, Wagner BA, Welsh MJ. Mitochondrial uncoupling proteins protect human airway epithelial ciliated cells from oxidative damage. Proceedings of the National Academy of Sciences. 121(10): e2318771121. (2024). https://doi.org/10.1073/pnas.2318771121

Yu W, Moninger TO, Rector MV, Stoltz DA, Welsh MJ. Pulmonary neuroendocrine cells sense succinate to stimulate myoepithelial cell contraction. Developmental Cell. 57(18): 2221‑2236.e5. (2022). https://doi.org/10.1016/j.devcel.2022.08.010

Thurman AL, Li X, Villacreses R, Yu W, Gong H, Mather SE, Romano‑Ibarra GS, Meyerholz DK, Stoltz DA, Welsh MJ, Thornell IM, Zabner J, Pezzulo AA. A single‑cell atlas of large and small airways at birth in a porcine model of cystic fibrosis. Am J Resp Cell Mol Bio. 66(6): 612‑622. (2022). https://doi.org/10.1165/rcmb.2021-0499OC

Yu W, Moninger TO, Thurman AL, Xie Y, Jain A, Zarei K, Powers LS, Pezzulo AA, Stoltz DA, Welsh MJ. Cellular and molecular architecture of submucosal glands in wild‑type and cystic fibrosis pigs. Proceedings of the National Academy of Sciences. 119(4): e2119759119. (2022). https://doi.org/10.1073/pnas.2119759119

Li M, Shao F, Qian Q, Yu W, Zhang Z, Chen B, Su D, Guo Y, Phan A‑V, Song L‑S, Stephens SB, Sebag J, Imai Y, Yang L, Cao H. A putative long noncoding RNA‑encoded micropeptide maintains cellular homeostasis in pancreatic β cells. Molecular Therapy – Nucleic Acids. 26: 307‑320. (2021). https://doi.org/10.1016/j.omtn.2021.06.027